Thermo Fisher Scientific NFRKB Recombinant Rabbit Monoclonal Antibody (4N8H3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4N8H3

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 370-495 of human NFRKB. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NFRKB,uniProtId:Q6P4R8-1,ncbiNodeId:9606,antigenRange:370-495,antigenLength:1299,antigenImageFileName:MA5-55502_NFRKB_Q6P4R8-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55502_NFRKB_Q6P4R8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.68 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: LGINEISSSF FSLLLEILLL ESQASLPMLE ERVLDWQSSP ASSLNSWFSA APNWAELVLP ALQYLAGESR AVPSSFSPFV EFKEKTQQWK LLGQSQDNEK ELAALFQLWL ETKDQAFCKQ ENEDSS

Target Information

NFRKB (nuclear factor related to kappa-B-binding protein) was first identified as a factor that could bind a variant NF-kappa B site in the interleukin-2 receptor alpha (IL-2R alpha) gene. NFRKB appears to be a transcription factor central to immune cell development. Evidence of this comes from the identification of NFRKB as an amplified gene in several cases of acute myeloid leukemia. Additionally, in another clinical case, a partial deletion of the chromosomal region that includes NFRKB is shown to be associated with combined cellular immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.