Thermo Fisher Scientific hnRNP-L Polyclonal Antibody
Rabbit polyclonal antibody against human hnRNP-L, suitable for WB, IHC, and IP applications. Recognizes residues 350–400 of hnRNP-L. Provided as liquid, unconjugated form at 1 mg/mL concentration. For research use only.
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Thermo Fisher Scientific hnRNP-L Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 350 and 400 of human Heterogeneous Nuclear Ribonucleoprotein L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
Target Information
Heterogeneous nuclear RNAs (hnRNAs), including mRNA precursors and mature mRNAs, are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes.
Heterogeneous nuclear ribonucleoprotein L (hnRNP-L) is among the proteins stably associated with hnRNP complexes and plays a major role in mRNA formation, packaging, processing, and function.
hnRNP-L is present in the nucleoplasm as part of the hnRNP complex but can also be found outside the nucleoplasm.
Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from nucleus to cytoplasm.
Since hnRNP proteins shuttle between nucleus and cytoplasm, they may also have cytoplasmic functions.
Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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