Thermo Fisher Scientific PTPN6/SHP1 Polyclonal Antibody
SHP-1(PTPN6) 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 인체 시료 반응성, 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 545 to 595 of Human Tyrosine-protein phosphatase non-receptor type 6 (SHP-1, UniProt ID: P29350-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase primarily expressed in hematopoietic cells. It contains two SH2 domains, a catalytic domain, and a regulatory domain. SHP-1 dephosphorylates target proteins to downregulate tyrosine kinase-regulated pathways. In hematopoietic cells, SHP-1 binds to phosphorylated erythropoietin receptors (EpoR) to negatively regulate growth. Overexpression in epithelial cells leads to dephosphorylation of the Ros receptor tyrosine kinase, reducing Ros-dependent proliferation. In myeloid cells, SHP-1 associates with the IL-3R beta chain to downregulate IL-3-induced phosphorylation and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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