Thermo Fisher Scientific KV2.2 (KCNB2) Polyclonal Antibody
Rabbit polyclonal antibody against human KV2.2 (KCNB2) for ICC/IF applications. Recognizes recombinant human KCNB2 protein. Suitable for neuronal excitability studies. Supplied as liquid, 0.2 mg/mL, stored in PBS with glycerol and sodium azide.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human KCNB2. Recombinant protein control fragment (Product #RP-107471) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664306 |
Product Specific Information
Immunogen sequence:
QHISTILLEET PSQGDRPLLG TEVSAPCQGP SKGLSPRFPK QKLFPFSSRE RRSFTEIDTG DDEDFLELP
Highest antigen sequence identity to the following orthologs:
- Mouse: 79%
- Rat: 81%
Target Information
KCNB2 (Kv2.2) encodes a voltage-gated potassium channel that regulates neuronal membrane excitability. Variations in K+ channel expression influence action potential waveforms and firing patterns in neurons. Kv2.2 channels are found in neuronal somata, dendrites, and various non-neuronal cells such as pancreatic islets, alveolar cells, and cardiac myocytes. Kv2.1 and KCNB2 form distinct K+ channel populations responsible for delayed rectifier-type (IK) currents in superior cervical ganglion cells. KCNB2 mediates voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with KCNB2 include Brugada Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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