Thermo Fisher Scientific EPB41L2 Polyclonal Antibody
Thermo Fisher Scientific의 EPB41L2 폴리클로날 항체로, Western blot, IHC, ICC/IF에 적합합니다. 사람 단백질에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human EPB41L2. Recombinant protein control fragment (Product # RP-102382) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789417 |
Product Specific Information
Immunogen sequence:
ESQSSLRRQK REKETSESRG ISRFIPPWLK KQKSYTLVVA KDGGDKKEPT QAVVEEQVLD KEEPLPEEQR QAKGDAEEMA QKKQEIKVEV KEEKPSVSKE EKPSVSKVEM QPTELVSKER EEKVKETQED KLEGGA
Target Information
The 4.1 gene family encodes a group of multifunctional cytoskeletal proteins (4.1R, 4.1G, 4.1N, and 4.1B), which are predominantly expressed in the nervous system.
4.1G stabilizes spectrin-actin interactions and is associated with hereditary elliptocytosis.
4.1R is essential for maintaining erythrocyte shape and membrane mechanical properties.
Both 4.1R and 4.1G are distributed in the cerebellum and modulate neuronal membrane mechanical properties by promoting fodrin/actin association.
4.1N (EPB41L1) and 4.1B (EPB41L3) are strongly expressed in the brain.
Antibodies to 4.1N detect multiple forms enriched in postsynaptic density preparations, while antibodies to 4.1B detect two forms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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