Thermo Fisher Scientific SCF Monoclonal Antibody (OTI5F6)
SCF 단백질을 인식하는 Mouse Monoclonal Antibody (Clone OTI5F6). Western blot, IHC, ICC/IF에 적합. Human 시료에 반응하며, Affinity Chromatography로 정제된 1 mg/mL 액상 제품. PBS/BSA/glycerol buffer에 보관, -20°C에서 안정적.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F6 |
| Immunogen | Full length human recombinant protein of KITLG produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725298 |
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and activation of signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression induces mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway decreases histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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