Thermo Fisher Scientific Phospho-Src (Tyr416) Recombinant Rabbit Monoclonal Antibody (SrcY416-C4)
Src 단백질의 Tyr416 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공. 인간 및 마우스 시료에 반응하며 Flow Cytometry 등 다양한 연구 응용 가능. HEK293 발현 시스템 기반으로 생산되어 로트 간 일관성 확보.
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Applications
- Flow Cytometry (Flow): 1–1,000 ng/mL
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SrcY416-C4 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr416 of human phospho Src |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896892 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in embryonic development and cell growth regulation. It associates with various cell surface receptors to facilitate signal transduction and plays roles in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, SRC is located on chromosome 20. Its activity is modulated by phosphorylation at Tyr416 (activation) and Tyr527 (inhibition). Mutations in SRC may contribute to malignant progression in colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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