Thermo Fisher Scientific Phospho-SQSTM1 (Ser349) Polyclonal Antibody
SQSTM1/p62 단백질의 Ser349 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot 및 IHC(Paraffin) 실험에 적합. Rabbit IgG 호스트, 액상 형태, 고순도 정제. 인산화 신호전달 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SQSTM1 (Accession Q13501), corresponding to amino acid residues around phosphorylated Ser349 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816131 |
Product Specific Information
Antibody detects endogenous levels of SQSTM1/p62 only when phosphorylated at Ser349.
Target Information
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway.
The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-κB in response to upstream signals.
Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene.
Mutations in this gene result in sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-104656_SQSTM1_Q13501-1_Rabbit.svg)
(이미지: PA5-104656_SQSTM1_Q13501-1_Rabbit_PDP.jpeg)
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