Thermo Fisher Scientific SQLE Polyclonal Antibody
Human SQLE 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:500~1:1,000 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS/glycerol buffer에 보관. 콜레스테롤 생합성 관련 연구용에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SQLE. Recombinant protein control fragment (Product #RP-91198) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647903 |
Product Specific Information
Immunogen sequence:
DGRKVTVIER DLKEPDRIVG EFLQPGGYHV LKDLGLGDTV EGLDAQVVNG YMIHDQESKS
EVQIPYPLSE NNQVQSGRAF HHGRFIMSLR KAAMAEPNAK FIEGVVLQLL EEDDVVMG- Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 81%
Target Information
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family.
It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure.
SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered rate-limiting).
It is post-translationally regulated by cholesterol-dependent proteasomal degradation.
The molecular weight (MW) of SQLE is approximately 64 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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