Thermo Fisher Scientific Pericentrin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: SH-SY5Y, Rat heart
• Immunogen sequence:
  GEKREDLEQL QQKQVNDHPP EQCGMFTVSD HPPEQHGMFT VGDHPPEQRG MFTVSDHPPE QHGMFTVSDH PPEQRGMFTI SDHQPEQRGM FTVSDHTPEQ RGIFTISDHP AEQRGMFT

Target Information

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas, although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70 kD component of a nucleosome remodeling deacetylase complex (NuRD), but it is more likely that this component is a different but very similar protein. These two proteins are closely related, sharing the same types of domains, including two DNA binding domains, a dimerization domain, and a domain commonly found in DNA methyltransferases. The profile and activity of this gene product suggest involvement in transcriptional regulation through chromatin remodeling.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.