Thermo Fisher Scientific Phospho-SKP1 (Thr131) Polyclonal Antibody
SKP1 단백질의 Thr131 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 원숭이, 랫트 반응성. 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SKP1 (Accession P63208), corresponding to amino acid residues around phosphorylated Thr131 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816734 |
Product Specific Information
Antibody detects endogenous levels of Skp1 only when phosphorylated at Thr131.
Target Information
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteasome. Specific F-box proteins recognize different target proteins, and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-105306_SKP1_P63208-1_Rabbit.svg)
(이미지: PA5-105306_SKP1_P63208-1_Rabbit_PDP.jpeg)
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