Thermo Fisher Scientific FBXW7 Polyclonal Antibody
FBXW7 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체. Western blot, IHC, ICC, Flow cytometry, IP에 사용 가능. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | - | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from an internal region of the human and mouse Cdc4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533451 |
Target Information
FBXW7 (F-Box and WD Repeat Domain Containing 7) is a member of the F-box protein family, characterized by a ~40 amino acid F-box motif. These proteins form part of the SCF (SKP1–Cullin–F-box) ubiquitin ligase complex, which mediates phosphorylation-dependent ubiquitination.
The F-box proteins are categorized into:
- Fbws: Containing WD-40 domains
- Fbls: Containing leucine-rich repeats
- Fbxs: Containing other interaction modules or no recognizable motifs
FBXW7 (also known as FBX30) belongs to the Fbws class and includes an F-box and seven tandem WD40 repeats. It binds directly to cyclin E, targeting it for ubiquitin-mediated degradation. Mutations in FBXW7 have been identified in ovarian and breast cancer cell lines, suggesting a role in tumorigenesis. Multiple transcript variants encoding different isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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