Thermo Fisher Scientific SLC24A2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 374-470. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SLC24A2,uniProtId:Q9UI40-1,ncbiNodeId:9606,antigenRange:374-470,antigenLength:661,antigenImageFileName:PA5-145209_SLC24A2_Q9UI40-1_Rabbit.svg,antigenImageFileNamePDP:PA5-145209_SLC24A2_Q9UI40-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3092047

Product Specific Information

Immunogen sequence: TEEGRFREKA SILHKIAKKK CHVDENERQN GAANHVEKIE LPNSTSTDVE MTPSSDASEP VQNGNLSHNI EGAEAQTADE EEDQPLSLAW PSETRKQ

Antigen sequence identity: Mouse 89%; Rat 81%

Target Information

NCKX2, also designated solute carrier family 24, member 2 (SLC24A2), belongs to a family of potassium-dependent sodium/calcium exchangers, all of which contain two large hydrophilic loops and two sets of multiple transmembrane-spanning segments. NCKX2 is expressed in neurons throughout the brain, with high expression found in cone photoreceptors in the retina as well as hippocampal pyramidal cells and the deep nuclei of the cerebellum. A critical component in the process of light adaptation, NCKX2 transports one calcium ion and one potassium ion in exchange for four sodium ions, thereby contolling calcium concentration in the eye during light and darkness. Additionally, NCKX2 regulates calcium levels in other cellular locations that experience rapid calcium fluxes, such as neuronal synapses. Inactivation of NCKX2 is believed to be an important regulatory mechanism in the control of sodium and calcium levels under different physiological conditions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.