Thermo Fisher Scientific GTF3C3/TFIIIC102 Polyclonal Antibody
Rabbit polyclonal antibody targeting human GTF3C3/TFIIIC102 for IHC applications. Recognizes multiple species with high sequence identity. Unconjugated, purified by antigen affinity chromatography, supplied in TBS buffer with BSA and sodium azide. For ...
- 카탈로그번호
- IHC00255x (2개 옵션)
- 판매단위
- pk
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and 525 of human general transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, X. tropicalis, Bovine, Dog, Horse, Rabbit, Guinea pig, Pig, Panda, Orangutan, Monkey, Gorilla, and Chimpanzee.
Target Information
RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors. To maintain rapid growth, cells must produce a high level of Pol III–transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex consists of five subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63, which are overexpressed in adenovirus-transformed and malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA Pol III and TFIIIB to promoter elements and may be key in deregulation of malignant cells.
TFIIIB includes TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1), and TFIIIB, all upregulated in transformed cells. Tumor suppressors RB and p53 are often inactivated in carcinomas, impairing their ability to regulate TFIIIB function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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