Thermo Fisher Scientific RFXANK Monoclonal Antibody (OTI3C10), TrueMAB
RFXANK 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. HEK293T 세포에서 생산된 full-length human recombinant protein을 면역원으로 사용. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol buffer에 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C10 |
| Immunogen | Full-length human recombinant protein of human RFXANK produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Major histocompatibility (MHC) class II molecules are transmembrane proteins with a central role in immune system development and regulation. The RFXANK protein, together with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters to activate transcription. This complex associates with MHC class II transactivator, controlling cell type specificity and inducibility of MHC class II gene expression. The protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene are linked to bare lymphocyte syndrome type II, complementation group B. Two transcript variants encoding different isoforms have been described, with only one isoform showing activation activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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