Thermo Fisher Scientific B4GALT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Product Specifications

Target Information

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that have exclusive specificity for the donor substrate UDP-galactose, transferring galactose in a beta1,4 linkage to acceptor sugars such as GlcNAc, Glc, and Xyl.
Each beta4GalT has a distinct role in the biosynthesis of various glycoconjugates and saccharide structures. As type II membrane proteins, they possess an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and remains uncleaved as a transmembrane anchor.

By sequence similarity, beta4GalTs form four groups:

• beta4GalT1 and beta4GalT2
• beta4GalT3 and beta4GalT4
• beta4GalT5 and beta4GalT6
• beta4GalT7

This gene is unique among beta4GalT genes because it encodes an enzyme participating in both glycoconjugate and lactose biosynthesis.
In glycoconjugate biosynthesis, the enzyme adds galactose to N-acetylglucosamine residues of monosaccharides or glycoprotein carbohydrate chains.
In lactose biosynthesis, occurring in lactating mammary tissues, the enzyme forms a heterodimer with alpha-lactalbumin to catalyze the reaction:
UDP-galactose + D-glucose <=> UDP + lactose.
The two enzymatic forms result from alternate transcription initiation sites and post-translational processing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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