Thermo Fisher Scientific TORC2 Polyclonal Antibody
TORC2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western Blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며 4°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1–4 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 475 and 500 of Human Transducer of Regulated cAMP Responsive Element-Binding Protein (CREB) 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) 2), and the related protein CRTC1 are potent CREB coactivators exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions.
Studies suggest that phosphorylation and nuclear/cytoplasmic shuttling of these proteins play an important role in regulating gluconeogenesis by cAMP.
CRTC2 is present in both B and T lymphocytes and abundantly expressed in the thymus. Its activity is crucial for regulating genes involved in cellular energy metabolism, while CRTC1 is essential for energy balance and fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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