Thermo Fisher Scientific Human PIAS3 Synthetic Peptide
Human PIAS3 단백질의 카복시 말단 12개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. PIAS3 관련 항체의 블로킹 실험에 사용됩니다. 고순도 정제 상태로 제공되며 PBS 버퍼에 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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- pk
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 12 amino acids near the carboxy terminus of human PIAS3.
PEP-1067 can be used as a blocking peptide with polyclonal antibody PA5-20953.
Target Information
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53, and steroid hormone signaling pathways.
The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3.
The major function of the PIAS proteins is the control of gene transcription and they can also act as small ubiquitin-like-modifier (SUMO) E3 ligases.
PIAS3 binds specifically to STAT3 following stimulation of STAT3.
Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T-/cell lymphomas, indicating that PIAS3 plays multiple roles in different tissues and cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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