Thermo Fisher Scientific SKP1 Polyclonal Antibody, MaxPab

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Protein sequence:
MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVGSTQFCL

Target Information

This gene encodes a component of SCF complexes, which include this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. SKP1 binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, targeting them for degradation by the proteasome. Specific F-box proteins recognize different target proteins, and many SCF substrates have been identified, including regulators of cell cycle progression and development. The protein also functions as an RNA polymerase II elongation factor. Alternative splicing results in two transcript variants, and a related pseudogene exists on chromosome 7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.