Thermo Fisher Scientific GADD45GIP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total GADD45GIP1 protein.

Target Information

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-κB signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta acts as part of the canonical IKK complex and phosphorylates inhibitors of NF-κB on two critical serine residues, leading to their polyubiquitination and proteasomal degradation.
Free NF-κB then translocates into the nucleus and activates transcription of numerous genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.