Thermo Fisher Scientific GADD45GIP1 Polyclonal Antibody
Human GADD45GIP1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:100 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. NF-κB 신호전달 연구용에 적합.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human GADD45GIP1 (aa 91–140) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635492 |
Product Specific Information
This antibody detects endogenous levels of total GADD45GIP1 protein.
Target Information
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-κB signaling pathway, which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
IKK beta acts as part of the canonical IKK complex and phosphorylates inhibitors of NF-κB on two critical serine residues, leading to their polyubiquitination and proteasomal degradation.
Free NF-κB then translocates into the nucleus and activates transcription of numerous genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can result in Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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