Thermo Fisher Scientific TCF7L2 Polyclonal Antibody
TCF7L2 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성이 있으며, Protein A로 정제된 고순도 항체입니다. Wnt 신호 경로 및 당대사 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TCF7L2, amino acids 401–550 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TCF7L2 (also known as TCF4) is a high mobility group (HMG) box-containing transcription factor involved in the Wnt signaling pathway. It regulates pro-glucagon gene expression, influencing glucose homeostasis and GLP-1 production. Genetic variants of TCF7L2 are associated with type 2 diabetes and play roles in beta-cell survival and function. Differential splicing isoforms of TCF7L2 are expressed during cancer progression, and gene targeting studies show its necessity for maintaining crypt stem cells in the small intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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