Thermo Fisher Scientific LON Polyclonal Antibody

Applications

ELISA (ELISA)

• Tested Dilution: 1:1,000–1:2,000
• Publications: -

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Escherichia coli LON PROTEASE.

Target Information

Lon protease is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins.
It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.
Lon protease degrades polypeptides processively to yield small peptide fragments (5–10 amino acids). It binds to DNA in a double-stranded, site-specific manner.

Endogenous substrates include regulatory proteins such as RcsA, SulA, SoxS, UmuD, and type II antitoxins (CcdA, HipB, MazE).
Overproduction inhibits translation through multiple pathways, including the YoeB-YefM toxin-antitoxin system, and leads to high persister cell formation, which confers antibiotic resistance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.