Thermo Fisher Scientific Selenoprotein W Polyclonal Antibody
인간 Selenoprotein W를 인식하는 Rabbit Polyclonal Antibody로 IHC(P) 등에 사용 가능. 고순도 친화 크로마토그래피 정제, 0.8 mg/mL 농도, PBS/glycerol buffer 보존. 근육 및 신경 발달 연구용으로 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:20–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Selenoprotein W |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2688455 |
Target Information
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
This protein is highly expressed in skeletal muscle, heart, and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function.
Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene for this locus has been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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