Thermo Fisher Scientific WNT1 Monoclonal Antibody (10C8)
Human 및 Mouse 시료에서 WNT1 단백질 검출용 단클론 항체로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합. 비결합형 액상 형태로 제공되며, 냉장 및 냉동 보관 가능. 세포 신호전달 및 암 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 10C8 |
| Immunogen | Purified recombinant fragment of WNT1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Ascites |
| Contains | 0.03% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet Ice |
| RRID | AB_10984682 |
Product Specific Information
MA5-15544 targets WNT1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and Mouse samples.
The immunogen is a purified recombinant fragment of WNT1 expressed in E. coli.
MA5-15544 detects WNT1 with a predicted molecular weight of approximately 41 kDa.
Target Information
Wnt proteins are a family of secreted glycoproteins that activate signal transduction pathways to regulate tissue homeostasis, cell fate, proliferation, and self-renewal.
The canonical pathway is initiated upon Wnt binding to a Frizzled receptor and LRP5/LRP6 coreceptor, activating the beta-catenin cascade.
Non-canonical Wnt signals involve Frizzled and ROR2 receptors. Deregulation of these pathways can lead to cancer.
Human Wnt-1 is encoded as a 370 amino acid precursor, cleaved into a 343 amino acid (42 kDa) mature form. Mature human Wnt-1 shares ~99% sequence identity with mouse Wnt-1. Depending on tissue context, Wnt-1 activates canonical and non-canonical signaling pathways and is involved in embryonic development and carcinogenesis.
Wnt-1 signaling can also induce phosphorylation and degradation of c-Myb.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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