Thermo Fisher Scientific PICALM/CALM Polyclonal Antibody
PICALM/CALM 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 Immunoprecipitation에 사용 가능. 인간 유래 항원(602-652 aa)으로 제작되었으며, 1 mg/mL 농도의 액상 형태로 제공. 4°C 보관, Wet ice 배송.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 602 to 652 of Human Phosphatidylinositol-binding clathrin assembly protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer’s disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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