Thermo Fisher Scientific GEMIN8 Polyclonal Antibody
GEMIN8 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 사용 가능. Human에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/glycerol buffer에 보관하며 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GEMIN8. Recombinant protein control fragment (Product #RP-92173). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2641956 |
Product Specific Information
Immunogen sequence:
ASTSKATRPW YSHPVYARYW QHYHQAMAWM QSHHNAYRKA VESCFNLPWY LPSALLPQSS YDNEAAYPQS FYDHHVAWQD YPCSSSHFRR SGQHPRYSSR IQASTKEDQA LSKEEEMETE SDAEVECDLS NMEITEELRQ YFAETER
Highest antigen sequence identity to the following orthologs:
- Mouse: 59%
- Rat: 60%
Target Information
The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), which are essential components of the spliceosome. It is critical for pre-mRNA splicing. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that form a heptameric ring around the Sm site of small nuclear RNA. The SMN complex facilitates the transition of Sm proteins from an inactive cytosolic complex (6S pICln-Sm) to the active SMN-Sm complex, enabling snRNP assembly and nuclear transport.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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