Thermo Fisher Scientific MARCH8 Polyclonal Antibody
MARCH8 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 유래 MARCH8 펩타이드로부터 제작되었으며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었고, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MARCH8 (Accession Q5T0T0), corresponding to amino acid residues E251–V291 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900182 |
Product Specific Information
Antibody detects endogenous levels of total MARCH8.
Target Information
MARCH8 (c-MIR) is a novel E3 ubiquitin ligase belonging to the modulator of immune recognition (MIR) family, characterized by a variant RING-CH domain. It functions as a homolog of KSHV MIR1 and MIR2, targeting B7-2 for lysosomal degradation and down-regulating its surface expression through ubiquitination. MARCH8 also down-regulates transferrin receptor and Fas, impacting apoptosis induction. It is the first E3 ubiquitin ligase known to inhibit MHC II expression. Recent studies suggest MARCH8 regulates immune responses by promoting ubiquitination of MHC-II and CD86, leading to endocytosis and lysosomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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