Thermo Fisher Scientific LYAR Polyclonal Antibody
상품 옵션 정보 | ||||||||
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA557444 | - | Thermo Fisher Scientific PA557444 LYAR Polyclonal Antibody 100 ul pk | 재고문의 | pk | 799,000원 | - | 878,900원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Immunohistochemistry (Paraffin) (IHC (P))
1:5,000-1:10,000
Immunocytochemistry (ICC/IF)
0.25-2 µg/mL
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human LYAR. Recombinant protein control fragment (Product #RP-96673). if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
LYAR,
uniProtId:
Q9NX58-1,
ncbiNodeId:
9606,
antigenRange:
95-195,
antigenLength:
379,
antigenImageFileName:
PA5-57444_LYAR_Q9NX58-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-57444_LYAR_Q9NX58-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2643621
Product Specific Information
Immunogen sequence: RELLEQISAF DNVPRKKAKF QNWMKNSLKV HNESILDQVW NIFSEASNSE PVNKEQDQRP LHPVANPHAE ISTKVPASKV KDAVEQQGEV KKNKRERKEE R
Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 67%.
Target Information
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5-GGTTAT-3
(PubMed:25092918). Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131). In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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