Thermo Fisher Scientific CRMP1 Polyclonal Antibody
CRMP1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 Protein A로 정제된 액상형 제품입니다. 신경세포 분화 및 축삭 성장 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human CRMP1 (amino acids 121–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain and play key roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in regions such as the cerebellum, hippocampus, and olfactory system suggests a role in adult brain plasticity.
CRMP-1, initially identified as a dihydropyrimidinase expressed in the brain, is involved in NT3-induced neurite formation and outgrowth. Its localization changes from axonal to somatodendritic as neurons mature, indicating a role in both early neuronal differentiation and later neuronal survival or death processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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