Thermo Fisher Scientific CD137 Recombinant Human Monoclonal Antibody (1H7)

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

Neutralization (Neu)

2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG2

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1H7

Immunogen

Recombinant Human TNFRSF9 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.03% Proclin 300

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

RRID

AB_3093051

Target Information

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.