Thermo Fisher Scientific Caspase 4 Polyclonal Antibody
Rabbit polyclonal antibody targeting Caspase 4 for detection in human and mouse samples. Suitable for Western blot and ELISA applications. Affinity purified and supplied in PBS with 50% glycerol. For research use only.
- 카탈로그번호
- PA593018
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 200–300 of mouse Caspase-4 (NP_0316352) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.22 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806590 |
Product Specific Information
- Positive Samples: U-87MG, HeLa
- Cellular Location: Endoplasmic reticulum membrane, Mitochondrion
- Immunogen Sequence:
FLVLMSHGTL HGICGTMHSE KTPDVLQYDT IYQIFNNCHC PGLRDKPKVI IVQACRGGNS GEMWIRESSK PQLCRGVDLP RNMEADAVKL SHVEKDFIAF Y
Target Information
This gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and large and small protease subunits. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme. Caspase 4 can cleave and activate its own precursor and that of caspase 1. Overexpression induces apoptosis. Alternative splicing results in distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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