Thermo Fisher Scientific IL18BP Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
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Product Specifications

Product Specific Information

PA1-4118 detects Interleukin-18 binding protein in human samples.
It has been successfully used in Western blot procedures.
By Western blot, this antibody detects a ~40 kDa protein representing Interleukin-18 binding protein in human spleen lysate.
The immunogen is a synthetic peptide corresponding to residues S(44) T K D P C P S Q P P V (55) of human IL-18BP.

Target Information

Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors.
Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity.

As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to diseases such as eczema, asthma, and Crohn’s disease.
Upregulation of IL-18BP by keratinocytes expressing the human papillomavirus (HPV) E7 oncoprotein decreases IL-18-induced IFN-gamma production and IL-18-mediated T cell activation.
Elevated levels of IL-18 and IL-18BP, as well as proinflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta, and IL-8, have been linked to chronic inflammation and observed in macrophages (including Kupffer cells) from Crohn’s disease lesions and intestinal tissues.

IL-18BP belongs to the immunoglobulin-like class of receptors, containing a single immunoglobulin (Ig) domain. Two of the four identified human isoforms (b and d) contain incomplete domains that greatly reduce their binding affinity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.