Thermo Fisher Scientific COIL Monoclonal Antibody (4B8)
COIL 단백질을 인식하는 Mouse IgM 단클론 항체(4B8)로, Western blot 및 ELISA에 적합합니다. Human 및 Mouse 시료에 반응하며, 비결합형 액상 형태로 제공됩니다. Cajal body 관련 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B8 |
| Immunogen | COIL (NP_004636, 477 a.a. ~575 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
IAFKLLELTS SYSPDVSDYK EGRILSHNPE TQQVDIEILS SLPALREPGK
FDLVYHNENG AEVVEYAVTQ ESKITVFWKE LIDPRLIIES PSNTSSTEPTarget Information
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies).
Cajal bodies are nuclear suborganelles involved in post-transcriptional modification of small nuclear and small nucleolar RNAs.
The N-terminus of coilin directs self-oligomerization, while the C-terminus influences the number of nuclear bodies per cell.
Differential methylation and phosphorylation of coilin affect its localization and composition within nuclear bodies.
This gene has pseudogenes on chromosome 4 and 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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