Thermo Fisher Scientific TSEN15 Polyclonal Antibody
Human TSEN15 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 고순도 항원 친화 크로마토그래피 정제. 비결합형 액상 형태로 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TSEN15. Recombinant protein control fragment (Product #RP-94557). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648986 |
Product Specific Information
Immunogen sequence:
EERGDSEPTP GCSGLGPDGV RGFGDGGGAP SWAPEDAWMG THPKYLEMME LDIGDATHVY VAFLVYLDLM ESK
Highest antigen sequence identity to orthologs:
- Mouse: 84%
- Rat: 84%
Target Information
TSEN15 is a non-catalytic subunit of the tRNA-splicing endonuclease complex, responsible for identifying and cleaving splice sites in pre-tRNA. It releases introns and generates tRNA half-molecules with 2',3'-cyclic phosphate and 5'-OH termini. Although splice sites lack conserved sequences, introns are consistently located at the same gene position. The complex also participates in mRNA processing through association with pre-mRNA 3'-end processing factors, linking tRNA splicing and mRNA 3'-end formation. This suggests multifunctional roles of endonuclease subunits in various RNA-processing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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