Thermo Fisher Scientific SCN2A Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
For reconstitution, add 50 µL of deionized water.

Target Information

Voltage-gated sodium channels are selective ion channels that regulate sodium ion permeability in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, rapidly depolarizing the cell.
The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal, and cardiac muscle.
In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels can lead to diseases such as myotonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.