Thermo Fisher Scientific CKMT Polyclonal Antibody
Thermo Fisher Scientific의 CKMT Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며, Western blot, IHC, ICC/IF, ELISA 등에 사용 가능합니다. Rabbit IgG 기반의 비결합 항체로, 고순도 Protein A 정제 및 안정한 보존 용액으로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Mitochondrial Creatine Kinase (amino acids 115–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mitochondrial creatine kinase (MtCK) transfers high-energy phosphate from mitochondria to the cytosolic carrier, creatine, and belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes—sarcomeric MtCK and ubiquitous MtCK—encoded by separate genes. MtCK forms both dimers and octamers, unlike cytosolic creatine kinase which forms only dimers. Overexpression of ubiquitous MtCK has been observed in malignant cancers with poor prognosis, possibly due to high energy turnover and impaired apoptosis. Two genes on chromosome 15 encode identical mitochondrial creatine kinase proteins with approximately 80% homology between sarcomeric and ubiquitous forms.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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