Thermo Fisher Scientific Tamtuvetmab Recombinant Canine Monoclonal Antibody

Thermo Fisher Scientific Tamtuvetmab Recombinant Canine Monoclonal Antibody

Applications

• ELISA (Assay-dependent)

Product Specifications

Product Specific Information

• Endotoxin level < 0.01 EU/µg (LAL method)
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week; -20 to -80°C for up to twelve months from receipt.

Target Information

Tamtuvetmab is a biosimilar antibody that targets nerve growth factor (NGF). NGF influences the survival and differentiation of various neuronal and nonneuronal cells through specific cell surface receptors with high and low affinity binding sites. Only the high affinity receptor mediates signal transduction.

Cross-linking studies with ¹²⁵I-NGF show that the high affinity receptor in rat PC12 cells forms a 158 kDa complex with NGF, while the low affinity receptor forms a 100 kDa complex. Full-length cDNA clones of both human and rat NGF receptor genes reveal over 90% homology.

NGF exhibits nerve growth stimulating activity and regulates the growth and differentiation of sympathetic and sensory neurons. It also stimulates division and differentiation of embryonic sensory neurons. Mutations in the NGF gene are linked to hereditary sensory and autonomic neuropathy type 5 (HSAN5), and dysregulation of NGF expression is associated with allergic rhinitis.

Usage Note

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.