Thermo Fisher Scientific HES6 Polyclonal Antibody
HES6 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제된 액상형 제품으로 안정적인 장기 보관 가능.
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Thermo Fisher Scientific HES6 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human HES6. Recombinant protein control fragment (Product #RP-107093) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856944 |
Product Specific Information
Immunogen sequence:
PIPSPPGPGD DLCSDLEEAP EAELSQAPAE GPDLVPAALG SLTTAQIARS VWRPW
Target Information
The HES family members form a complex with TLE, the mammalian homologue of Groucho, mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) rather than the E box (CANNTG).
HES2 binds to both N and E box sites, while HES6 does not bind DNA. Instead, HES6 inhibits HES1 activity and promotes transcription.
HES1 and HES2 are expressed in various adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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