Thermo Fisher Scientific ULBP1 Recombinant Rabbit Monoclonal Antibody (13C8)
ULBP1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 사용 가능. 인간 특이적 반응성을 가지며 HEK293 세포에서 발현. 고순도 친화성 크로마토그래피로 정제되어 안정적인 액상 형태로 제공. 연구용으로만 사용.
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- MA550072
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 13C8 |
| Immunogen | A synthesized peptide derived from human ULBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092846 |
Target Information
ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3.
ULBPs activate multiple signaling pathways in primary NK cells, resulting in cytokine and chemokine production.
Binding of ULBP ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK, and PI3K/Akt pathways.
In CMV-infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16, which blocks NKG2D receptor binding, allowing immune evasion.
UL16 also causes ULBP1 retention in the ER and cis-Golgi apparatus, preventing surface expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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