
Thermo Fisher Scientific ALK Monoclonal Antibody (OTI4D1), TrueMAB
인간 ALK 단백질(aa 1060-1620)에 특이적인 Mouse IgG1 단클론 항체로, Western blot에 1:2,000 희석으로 검증됨. 액상형, 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 뇌 발달 관련 연구 및 암 유전자 변이 연구용.
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Applications
- Western Blot (WB): Tested at 1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development. Mutations, rearrangements, and amplifications in the ALK gene have been linked to tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. The most common genetic alteration is chromosomal rearrangement that creates a fusion gene between ALK and nucleophosmin (NPM). The NPM-ALK fusion product is oncogenic. ALK is a novel receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK. It is essential for neuronal development and signaling in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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