Thermo Fisher Scientific PDCL3 Polyclonal Antibody
Human PDCL3 단백질을 인식하는 Rabbit Polyclonal Antibody로 WB, IHC, ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. PDCL3 관련 세포골격 조절 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDCL3. Recombinant protein control fragment (Product #RP-92034). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645320 |
Product Specific Information
Immunogen sequence:
EWNDILRKKG ILPPKESLKE LEEEAEEEQR ILQQSVVKTY EDMTLEELED HEDEFNEEDE RAIEMYRRRR LAEWKATKLK
Antigen sequence identity:
- Mouse: 86%
- Rat: 85%
Target Information
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes promotes cytoskeletal remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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