Thermo Fisher Scientific CACNG1 Polyclonal Antibody, MaxPab
CACNG1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Western blot 및 유세포 분석에 적합합니다. 인간 시료에 반응하며, 액상 형태로 제공되고 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Flow Cytometry (Flow) | 1×10⁶ cells / 50 µL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CACNG1 (NP_000718.1, 1 a.a. – approximately 222 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH FGLWRICTKR IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ KEYSISAAAI AIFSLGFIIL GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW SFACACAAFI LLFLGGLALL LFSLPRMPRN PWESCMDAEP EH
Target Information
Voltage-dependent calcium channels are essential for neurotransmitter release. L-type (long-lasting current) voltage-dependent calcium channels consist of four subunits: alpha1, beta, gamma, and alpha2 delta. The beta subunit is encoded by four genes (beta1–beta4), contributing to calcium current diversity and membrane trafficking of the alpha1 subunit.
L-type Ca²⁺ channel gamma1 (CACNG1, also known as CACNLG) is a 222-amino-acid multi-pass membrane protein of the PMP-22/EMP/MP20 family, expressed in skeletal muscle. It is a subunit of the dihydropyridine (DHP)-sensitive calcium channel and may play a role in excitation–contraction coupling. CACNG1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant skeletal muscle disorder characterized by a hypermetabolic crisis triggered by certain anesthetics and muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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