ELK Biotechnology HDAC3 rabbit pAb
HDAC3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 HDAC3 유래 펩타이드로부터 제작되었으며, 핵과 세포질에서 발현되는 HDAC3 검출에 유용합니다. 고순도 IgG, 1 mg/ml 농도, -20°C 보관.
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HDAC3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | HDAC3 rabbit pAb |
| Alternative Names | HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC3 (AA range: 379–428) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| Gene ID (Human) | 8841 |
| Human Swiss-Prot No | O15379 |
| Cellular Localization | Nucleus; Cytoplasm; Cytosol. Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). |
| Species Reactivity | Human; Mouse; Rat |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. (RefSeq, Jul 2008)
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