Thermo Fisher Scientific HPK1 Polyclonal Antibody
HPK1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot과 Immunocytochemistry에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 액상 형태로 제공되고 -20°C에서 보관합니다. MAP4K1 유래 펩타이드를 면역원으로 사용하여 높은 특이성과 재현성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP4K1 (Accession Q92918), amino acid residues S377–R427 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854191 |
Product Specific Information
Antibody detects endogenous levels of total HPK1.
Target Information
MAP4K1 (also known as HPK1, Hematopoietic progenitor kinase 1) is a hematopoietic cell-restricted member of the Ste20 serine/threonine kinase superfamily.
It acts as a tissue-specific upstream activator of the MEKK/JNK/SAPK signaling pathway and regulates T cell receptor (TCR) signaling and proliferation by phosphorylating the adaptor protein SLP-76.
HPK1 plays a crucial role in stress responses and blood cell differentiation. It is predominantly expressed in hematopoietic cells, including early progenitor cells, and is related to p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20.
HPK1 specifically activates JNK1 and enhances AP-1-mediated transcriptional activity in vivo. Unlike PAK65, HPK1 does not bind to Rac1 or Cdc42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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