Thermo Fisher Scientific ZAP70 Recombinant Rabbit Monoclonal Antibody (ZAP70, 3921R)
ZAP70 단백질을 인식하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. 인간 시료에 반응하며 IHC(Paraffin)에서 검증됨. 고순도 Protein A/G 정제, 200 µg/mL 농도, PBS 기반 보존용액. T세포 수용체 활성화 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ZAP70, 3921R |
| Immunogen | Recombinant fragment (around aa 247–382) of human ZAP70 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase belonging to the Syk family. It is expressed exclusively in T-cells and natural killer cells and is essential for T-cell receptor activation.
Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315, and 319 in the interdomain B region between the SH2 and kinase domains.
Phosphorylation of tyrosines 315 (Vav binding site) and 319 (Lck binding site) enhances ZAP70 function in lymphocyte signaling, while phosphorylation at tyrosine 292 terminates transient activation and attenuates signaling.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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