Thermo Fisher Scientific RNF169 Monoclonal Antibody (3B6)
RNF169 단백질을 인식하는 Mouse monoclonal antibody로, Western blot 및 ELISA에 적합. 인간 시료에 반응하며, 비접합(Unconjugated) 형태로 제공. DNA 손상 복구 연구 및 단백질 상호작용 분석에 유용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B6 |
| Immunogen | RNF169 (XP_495886, 643 a.a. ~742 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SLSEEPLPSL RRGRKRHCKT KHLEQNGSLK KLRQTSGEVG LAPTDPVLRE MEQKLQQEEE DRQLALQLQR MFDNERRTVS RRKGSVDQYL LRSSNMAGAK
Target Information
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage.
Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair.
E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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