Thermo Fisher Scientific IRS1 Polyclonal Antibody
IRS1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, IP 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되었으며, 인간 및 마우스 반응성. 4°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1192 and 1242 of human insulin receptor substrate 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
IRS-1 (Insulin Receptor Substrate 1) is a major substrate of the insulin receptor. It is phosphorylated in response to insulin, insulin-like growth factor 1 (IGF-1), and interleukin 4 (IL-4) stimulation.
IRS-1 undergoes phosphorylation on serine, threonine, and tyrosine residues across various tissues. Casein kinase II mediates a portion of insulin-stimulated serine/threonine phosphorylation in vivo, with Thr502 and Ser99 identified as key phosphorylation sites.
IRS-1 contains three putative 14-3-3 binding sites (Ser270, Ser374, Ser641), with the Ser270 motif located in the phosphotyrosine-binding domain responsible for interaction with the insulin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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