Thermo Fisher Scientific Phospho-Doublecortin (Ser332) Polyclonal Antibody
Doublecortin 단백질의 Ser332 인산화 상태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot에 최적화되어 있으며 인간, 마우스, 랫트 시료에 반응. PBS/glycerol buffer에 보관, -20°C에서 안정적. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DCX (Accession O43602), corresponding to amino acid residues around phosphorylated Ser332 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816829 |
Product Specific Information
Antibody detects endogenous levels of Doublecortin only when phosphorylated at Ser332.
Target Information
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein that directs neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains that bind microtubules. Additionally, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, which is essential for proper microtubule function in the developing cortex. Mutations in the DCX gene are associated with X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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