Thermo Fisher Scientific Collagen I Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• PA1-27396 will not react with human, rat, or chicken.
• This product is unsuitable for western blot.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. It is a member of group I collagen (fibril-forming collagen) found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms associated with COL1A2 mutations tend to be less severe than those in COL1A1, reflecting the different roles of alpha-2 chains in matrix integrity.
Reciprocal translocations between chromosomes 17 and 22, involving Collagen Type I genes and the gene for platelet-derived growth factor beta, are linked to dermatofibrosarcoma protuberans, resulting from unregulated growth factor expression.
Two transcripts, resulting from alternate polyadenylation signals, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.