Thermo Fisher Scientific ZFYVE21 Polyclonal Antibody
인간 ZFYVE21 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 면역조직화학(IHC) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 형태. 세포 부착 및 이동 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZFYVE21. Recombinant protein control fragment (Product #RP-98355). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649910 |
Product Specific Information
Immunogen sequence:
SGATFLVTFG NSEKPETMTC RLSNNQRYLF LDGDSHYEIE IVHISTVQIL TEGFPPGGGN ARATGMFLQY TVPG
Highest antigen sequence identity to the following orthologs:
- Mouse: 82%
- Rat: 84%
Target Information
ZF21 was initially identified as a protein that binds to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease.
ZF21 belongs to a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement.
Knockdown of ZF21 expression delays FA disassembly following nocodazole-induced synchronous disassembly, suggesting ZF21’s role in FA disassembly.
ZF21 contains a noncanonical pleckstrin homology domain, which may serve as a therapeutic target for metastatic cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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