Thermo Fisher Scientific ZFYVE21 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZFYVE21. Recombinant protein control fragment (Product #RP-98355). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZFYVE21,uniProtId:Q9BQ24-1,ncbiNodeId:9606,antigenRange:119-192,antigenLength:234,antigenImageFileName:PA5-63165_ZFYVE21_Q9BQ24-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63165_ZFYVE21_Q9BQ24-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649910

Product Specific Information

Immunogen sequence: SGATFLVTFG NSEKPETMTC RLSNNQRYLF LDGDSHYEIE IVHISTVQIL TEGFPPGGGN ARATGMFLQY TVPG

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 84%.

Target Information

ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.